Analysis of the factors affecting the evolution over time of subclinical hypothyroidism in children. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Valenzise, Mariella; Aversa, Tommaso; Zirilli, Giuseppina; Salzano, Giuseppina; Corica, Domenico; Santucci, Simona; De Luca, Filippo
• Is Part Of: Italian journal of pediatrics. Volume 43:Issue 1(2017)
• Page Start: 1
• Page End: 6
• Publication Date: 2017-12
• Subjects: Chromosomopathies -- Down's syndrome -- Hashimoto's thyroiditis -- Thyroid function -- Thyroid status -- Turner syndrome; Pediatrics -- Periodicals; 618.920005
• DOI: 10.1186/s13052-016-0322-z
• Languages: English
• ISSNs: 1824-7288

Abstract

Abstract Aim of this commentary is to report the most recent views about natural history of subclinical hypothyroidism (SH) according to the different etiologies. In children with idiopathic SH the natural evolution is often favourable, with a high percentage of cases reverting to euthyroidism or remaining SH even after a prolonged follow-up. By contrast, the risk of a significant deterioration of thyroid status is distinctly higher in the SH children with Hashimoto's thyroiditis (HT). This risk is even higher in the cases with both HT-related SH and chromosomal abnormalities, such as Turner or Down's syndrome.