Primary hyperparathyroidism in pregnancy treated with cinacalcet: a case report and review of the literature. (December 2016)

• Record Type: Journal Article
• Authors: Vera, Lara; Oddo, Silvia; Di Iorgi, Natascia; Bentivoglio, Giorgio; Giusti, Massimo
• Is Part Of: Journal of medical case reports. Volume 10:Number 1(2016)
• Page Start: 1
• Page End: 5
• Publication Date: 2016-12
• Subjects: Cinacalcet -- Calcimimetic -- Pregnancy -- Primary hyperparathyroidism -- Hypercalcemia -- Case report; Medicine -- Research -- Periodicals; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1186/s13256-016-1093-2
• Languages: English
• ISSNs: 1752-1947

Abstract

Abstract Background The efficacy and safety of various modes of medical treatment for primary hyperparathyroidism in pregnancy are largely unknown. Case presentation We report the case of a 34-year-old white woman with primary hyperparathyroidism symptomatic for nephrolithiasis. Her serum calcium was 3.15 mmol/l and parathyroid hormone was 109.0 ng/L. Neck imaging found no pathological parathyroid tissue. Cinacalcet and cholecalciferol were started. She became pregnant 17 months later. The calcimimetic was stopped. During pregnancy, she was admitted for hydration administered intravenously two to three times per week. In her 24th week of pregnancy, cinacalcet was restarted. In her 32nd week, a cesarean section was carried out as planned. Conclusions Only three cases of primary hyperparathyroidism in women on cinacalcet therapy in pregnancy have been published in the literature. In the present case, hydration was useful in controlling serum calcium. Cinacalcet therapy helped to control serum calcium.