Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Schmidt, Simone; Rollnik, Jens
• Is Part Of: BMC neurology. Volume 16:Issue 1(2016)
• Page Start: 1
• Page End: 7
• Publication Date: 2016-12
• Subjects: Critical illness polyneuropathy -- CIP -- Early rehabilitation -- Diagnosis -- Pathophysiology -- Outcome; Neurology -- Periodicals; 616.8005
• DOI: 10.1186/s12883-016-0775-0
• Languages: English
• ISSNs: 1471-2377

Abstract

Abstract Background Critical illness polyneuropathy (CIP) is a complex disease affecting 30–70% of critically ill patients. Methods Clinical (Barthel index, length of stay (LOS), morbidity, duration of mechanical ventilation, routine lab results) and neurophysiological (neurography) data of 191 patients admitted to neurological early rehabilitation and diagnosed with CIP have been analyzed retrospectively. Results CIP diagnosis was correct in 159 cases (83%). In this study, systemic inflammation, sepsis, systemic inflammatory response syndrome (SIRS), multiple organic failure (MOF), chronic renal failure, liver dysfunction, mechanical ventilation, diabetes, dyslipidemia and impaired ion homeostasis (hypocalcaemia, hypokalemia) were associated with CIP. Neurography, in particular of the peroneal, sural, tibial and median nerves, helped to identify CIP patients. Compound muscle action potential amplitude (r = −0.324, p < 0.05), as well as sensory (r = −0.389, p < 0.05) and motor conduction velocity (r = −0.347, p < 0.05) of the median nerve correlated with LOS in neurological early rehabilitation but not with outcome measures. Conclusions In most cases, diagnosis of CIP among neurological early rehabilitation patients seems to be correct. Neurography may help to verify the diagnosis and to learn more about CIP pathophysiology, but it does not allow outcome prediction. Further studies on CIP are strongly encouraged.