Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Kasuga, Jun; Kawahara, Takashi; Takamoto, Daiji; Fukui, Sachi; Tokita, Takashi; Tadenuma, Tomoyuki; Narahara, Masaki; Fusayasu, Syusei; Terao, Hideyuki; Izumi, Koji; Ito, Hiroki; Hattori, Yusuke; Teranishi, Jun-ichi; Sasaki, Takeshi; Makiyama, Kazuhide; Miyoshi, Yasuhide; Yao, Masahiro; Yumura, Yasushi; Miyamoto, Hiroshi; Uemura, Hiroji
• Is Part Of: BMC cancer. Volume 16:Issue 1(2016)
• Page Start: 1
• Page End: 6
• Publication Date: 2016-12
• Subjects: Penile cancer -- Biomarker -- Neutrophil-to-lymphocyte ratio -- Immunohistochemistry; Cancer -- Periodicals; 616.994005
• DOI: 10.1186/s12885-016-2443-6
• Languages: English
• ISSNs: 1471-2407

Abstract

Abstract Background The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer. Methods A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer. Results The median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR. Conclusions The pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.