Atopy and autoimmune thyroid diseases: melatonin can be useful?. Issue 1 (December 2016)
- Record Type:
- Journal Article
- Title:
- Atopy and autoimmune thyroid diseases: melatonin can be useful?. Issue 1 (December 2016)
- Main Title:
- Atopy and autoimmune thyroid diseases: melatonin can be useful?
- Authors:
- D'Angelo, Gabriella
Marseglia, Lucia
Manti, Sara
Colavita, Laura
Cuppari, Caterina
Impellizzeri, Pietro
Arena, Salvatore
Arrigo, Teresa
Salpietro, Carmelo
Gitto, Eloisa - Abstract:
- Abstract Recently, there has been growing interest in the relationship between allergic and autoimmune diseases. Allergy and autoimmunity can be considered two potential outcomes of dysregulated immunity and analysis of literature data shows a strong positive association between a history of Th2-mediated allergic disorders and Th1-mediated autoimmune disorders. Autoimmune thyroid diseases are the most common of all autoimmune pathological conditions. Currently, the mechanisms explaining an association among atopy, autoimmunity, and thyroid diseases are not fully understood. There are data in literature pointing to the relationship between melatonin and thyroid activity. Several studies have suggested a paracrine role for this molecule in the regulation of thyroid activity, documenting that administration, as an antioxidant, in thyroid tissues under conditions of increased oxidative stress, could be helpful to reduce the oxidative processes involved in autoimmune thyroid diseases. Although thyroid autoimmunity has been regularly associated with atopic conditions in children, the possible protective role of melatonin has not yet been investigated. This review summarizes what is known regarding the connection between atopy and autoimmune thyroid diseases, and analyses the probable beneficial action of melatonin.
- Is Part Of:
- Italian journal of pediatrics. Volume 42:Issue 1(2016)
- Journal:
- Italian journal of pediatrics
- Issue:
- Volume 42:Issue 1(2016)
- Issue Display:
- Volume 42, Issue 1 (2016)
- Year:
- 2016
- Volume:
- 42
- Issue:
- 1
- Issue Sort Value:
- 2016-0042-0001-0000
- Page Start:
- 1
- Page End:
- 6
- Publication Date:
- 2016-12
- Subjects:
- Thyroid autoimmunity -- Allergic diseases -- Dysregulated immune system -- Melatonin
Pediatrics -- Periodicals
618.920005 - Journal URLs:
- http://www.ijponline.net/ ↗
http://link.springer.com/ ↗
http://www.ijp.it ↗ - DOI:
- 10.1186/s13052-016-0305-0 ↗
- Languages:
- English
- ISSNs:
- 1824-7288
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 9958.xml