Treatment and control of bovine hypodermosis with ivermectin long-acting injection (IVOMEC® GOLD). Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Otranto, Domenico; Johnson, Greg; Syvrud, Kevin; Yoon, Stephen; Hunter, James; Rehbein, Steffen
• Is Part Of: Parasites & vectors. Volume 9:Issue 1(2016)
• Page Start: 1
• Page End: 6
• Publication Date: 2016-12
• Subjects: Ivermectin -- Long-acting injection -- Efficacy -- Hypoderma bovis -- Hypoderma lineatum -- Cattle; Parasitism -- Periodicals; Parasites -- Periodicals; Vector-pathogen relationships -- Periodicals; Animals as carriers of disease -- Periodicals; Insects as carriers of disease -- Periodicals; 616.96
• DOI: 10.1186/s13071-016-1823-8
• Languages: English
• ISSNs: 1756-3305

Abstract

Abstract Background The studies reported here were conducted to assess the efficacy of ivermectin long-acting injection (IVM LAI; IVOMEC® GOLD, Merial; 3.15 % w/v ivermectin) for the treatment and control of natural infestations of cattle byHypoderma bovis andHypoderma lineatum, which are the most economically important oestrid flies of cattle in the northern hemisphere. Methods Cattle selected from herds with a history ofHypoderma infestation were grouped into blocks of three (Italy, 33 cattle; Germany, 30 cattle) or two (USA, 16 cattle) animals each, on the basis of positivity at the pre-treatment anti-Hypoderma antibody titres. Within each block, animals were randomly allocated to one of the following treatment regimens: saline (control); IVM LAI, administered at the predicted time of occurrence of first-instar larvae (Italy, Germany, USA); IVM LAI, administered at the predicted time of occurrence of second- and/or third-instar larvae (Italy, Germany). All treatments were administered by subcutaneous injection in correspondence of the area anterior to the shoulder at 1 ml/50 kg body weight, which corresponds to 630 mcg IVM/kg for IVM LAI. Results NoHypoderma larvae emerged from animals treated with IVM LAI, whereas liveH. lineatum (Italy) orH. bovis (Germany, USA) larvae were collected from saline-treated animals (P < 0.01). No adverse reactions to treatments were in any of the animals enrolled in the study. Conclusions The results from this study demonstrate that ivermectin in a long-acting formulation is 100 % efficacious in the treatment of cattle naturally infested byH. bovis andH. lineatum larvae at all stages of development. IVM LAI can, therefore, be used as 'prophylactic' treatment forHypoderma spp. infestations in absence of external evidence of their presence and thus prior to skin and carcass damage, and as 'therapeutic' treatment, when warbles are already present.