The effect of lifestyle intervention in obesity on the soluble form of activated leukocyte cell adhesion molecule. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Sulaj, Alba; Zemva, Johanna; Zech, Ulrike; Woehning, Annika; Brune, Maik; Rudofsky, Gottfried; Nawroth, Peter; Fleming, Thomas; von Bauer, Rüdiger
• Is Part Of: BMC endocrine disorders. Volume 16:Issue 1(2016)
• Page Start: 1
• Page End: 7
• Publication Date: 2016-12
• Subjects: Obesity -- Lifestyle intervention -- Insulin resistance -- sALCAM -- Cell adhesion molecule; Endocrine glands -- Diseases -- Periodicals; 616.4005
• DOI: 10.1186/s12902-016-0138-2
• Languages: English
• ISSNs: 1472-6823

Abstract

Abstract Background The aim of this study was to investigate the effect of a lifestyle intervention in obesity on the soluble form of the activated leukocyte cell adhesion molecule (sALCAM) and its association with metabolic parameters. Methods Twenty-nine obese subjects selected from the OPTIFAST®52 program. This program consisted into 2 crucial phases: an initial 12-week active weight reduction phase, followed by a 40-week weight maintenance phase. At baseline, after 12 weeks and at the end of the program, fasting glucose and insulin, total cholesterol, LDL-C, HDL-C, triglycerides, adiponectin, leptin, high sensitivity CRP, sALCAM, homeostasis model assessment-estimated insulin resistance (HOMA-IR) and leptin-to-adiponectin-ratio were determined. Oral glucose tolerance test (OGTT) was performed when indicated. Results At baseline, the serum concentration of sALCAM was increased and correlated positively with HOMA-IR and negatively with age. At the end of the program, sALCAM concentrations decreased significantly. Multivariate analysis showed that sALCAM significantly correlated with age, glucose concentration after 2 h OGTT and the HOMA-IR. A higher decrease of HOMA-IR during the study was observed in subjects with higher concentration of sALCAM at baseline. Conclusions sALCAM might be a novel biomarker in obesity that correlates and predicts insulin sensitivity improvement and that can be affected by lifestyle intervention.