Periplakin is a target for autoimmunity in asthma. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Taillé, Camille; Grootenboer-Mignot, Sabine; Estellat, Candice; Roy, Carine; Ly Ka So, Sophie; Pretolani, Marina; Aubier, Michel; Crestani, Bruno; Chollet-Martin, Sylvie
• Is Part Of: Respiratory research. Volume 17:Issue 1(2016)
• Page Start: 1
• Page End: 4
• Publication Date: 2016-12
• Subjects: Airway epithelium -- Asthma -- Autoimmunity -- Desmosome -- Nasal polyposis; Respiratory organs -- Diseases -- Periodicals; 616.2005
• DOI: 10.1186/s12931-016-0441-5
• Languages: English
• ISSNs: 1465-993X

Abstract

Abstract The role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients with asthma, with no association with severity or atopy. In addition, anti-periplakin IgE antibodies were detected in 12 of 138 tested patients (8.7 %) and were more frequently observed in patients with than without nasal polyposis. This study identifies a new autoimmune epithelial target in asthma. Whether periplakin autoimmunity (both IgG and IgE auto-antibodies) is involved in asthma pathogenesis remains to be studied during the disease course of these patients.