Investigation of an unusual increase in human yersinioses in Creuse, France. (May 2015)

• Record Type: Journal Article
• Authors: Martin, Liliane; Cabanel, Nicolas; Lesoille, Christelle; Ménard, Thierry; Carniel, Elisabeth
• Is Part Of: International journal of infectious diseases. Volume 34(2015:May)
• Page Start: 76
• Page End: 78
• Publication Date: 2015-05
• Subjects: Yersinia enterocolitica -- epidemiology -- enteropathogen -- diarrhoea -- MLVA -- PFGE; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2015.03.011
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Unusual number of human Y. enterocolitica infections in Creuse between 2008 and 2010 Genetically highly diverse pathogenic Y. enterocolitica isolates No common source of contamination Increased cases in Creuse not correlated with a national increase in yersinioses Favourable local environmental conditions likely responsible for this transient increase Summary: Objectives: To investigate an unusual cluster of Y. enterocolitica 4/O:3/VIII human infections that occurred in Creuse (France) during the summer 2008, and to perform retrospective and prospective analyses of yersiniosis cases to get a better view of the general trend. Methods: 33 pathogenic Y. enterocolitica strains isolated between 2008 and 2010 in Creuse were subjected to phenotypic and molecular typing. The database of the Yersinia National Reference Laboratory was used to compare the number of human cases over 23 years in Creuse and at the national level. Results: The 33 isolates had three distinct phenotypes and a high genetic diversity, ruling out a unique source of contamination. A long-term analysis of yersiniosis cases in Creuse showed a progressive increase over years, with a peak in 2008 and a subsequent decrease. This trend contrasted with the national cases that showed an opposite pattern. Conclusions: Local environmental conditions were most likely responsible for a transient expansion of pathogenic Y. enterocolitica strains in Creuse.