Manganese‐Catalyzed Carbonylative Annulations for Redox‐Neutral Late‐Stage Diversification. Issue 19 (6th April 2018)

• Record Type: Journal Article
• Authors: Liang, Yu‐Feng; Steinbock, Ralf; Münch, Annika; Stalke, Dietmar; Ackermann, Lutz
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 19(2018)
• Page Start: 5384
• Page End: 5388
• Publication Date: 2018-04-06
• Subjects: annulation -- carbonylation -- late-stage modification -- manganese -- traceless directing groups; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201801111
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: An inexpensive, nontoxic manganese catalyst enabled unprecedented redox‐neutral carbonylative annulations under ambient pressure. The manganese catalyst outperformed all other typically used base and precious‐metal catalysts. The outstanding versatility of the manganese catalysis manifold was reflected by ample substrate scope, setting the stage for effective late‐stage manipulations under racemization‐free conditions of a wealth of marketed drugs and natural products, including alkaloids, amino acids, steroids, and carbohydrates. Abstract : Smart Man : An inexpensive, nontoxic manganese complex catalyzed carbonylative alkyne annulation reactions to form pyrido[1, 2‐ a ]pyrimidin‐4‐ones under ambient pressure. The manganese catalyst outperformed other typically used metal catalysts and showed outstanding versatility, as reflected by the modification of various marketed drugs and natural products, including alkaloids, amino acids, steroids, and carbohydrates.