The mechanosensor of mesenchymal stem cells: mechanosensitive channel or cytoskeleton?. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Xiao, E.; Chen, Chider; Zhang, Yi
• Is Part Of: Stem cell research & therapy. Volume 7:Issue 1(2016)
• Page Start: 1
• Page End: 4
• Publication Date: 2016-12
• Subjects: Mesenchymal stem cells -- Mechanosensation -- TRPM7 -- Cytoskeleton; Stem cells -- Research -- Periodicals; Cellular therapy -- Periodicals; 616.0277405
• DOI: 10.1186/s13287-016-0397-x
• Languages: English
• ISSNs: 1757-6512

Abstract

Abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells. MSCs and their potential for use in regenerative medicine have been investigated extensively. Recently, the mechanisms by which MSCs detect mechanical stimuli have been described in detail. As in other cell types, both mechanosensitive channels, such as transient receptor potential melastatin 7 (TRPM7), and the cytoskeleton, including actin and actomyosin, have been implicated in mechanosensation in MSCs. This review will focus on discussing the precise role of TRPM7 and the cytoskeleton in mechanosensation in MSCs.