Ultra‐Specific Isolation of Circulating Tumor Cells Enables Rare‐Cell RNA Profiling. Issue 9 (18th April 2016)

• Record Type: Journal Article
• Authors: Jack, Rhonda M.; Grafton, Meggie M. G.; Rodrigues, Danika; Giraldez, Maria D.; Griffith, Catherine; Cieslak, Robert; Zeinali, Mina; Kumar Sinha, Chandan; Azizi, Ebrahim; Wicha, Max; Tewari, Muneesh; Simeone, Diane M.; Nagrath, Sunitha
• Is Part Of: Advanced science. Volume 3:Issue 9(2016:Sep.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-04-18
• Subjects: cell sorting -- immunomagnetism -- microfluidics -- mRNA -- tumor cells; Science -- Periodicals; 505
• DOI: 10.1002/advs.201600063
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : The clinical potential of circulating tumor cells (CTCs) in managing cancer metastasis is significant. However, low CTC isolation purities from patient blood have hindered sensitive molecular assays of these rare cells. Described herein is the ultra‐pure isolation of CTCs from patient blood samples and how this platform has enabled highly specific molecular (mRNA and miRNA) profiling of patient CTCs.