The Brave New World of clinical cancer research: Adaptive biomarker‐driven trials integrating clinical practice with clinical research1. Issue 5 (11th March 2015)

• Record Type: Journal Article
• Authors: Berry, Donald A.
• Other Names: Mendelsohn John specialEditor.; Ringborg Ulrik specialEditor.; Schilsky Richard specialEditor.
• Is Part Of: Molecular oncology. Volume 9:Issue 5(2015:May)
• Page Start: 951
• Page End: 959
• Publication Date: 2015-03-11
• Subjects: Biomarker-driven clinical trials -- Platform trials -- Basket trials -- Bayesian adaptive clinical trials; Cancer -- Molecular aspects -- Periodicals; 616.994005
• DOI: 10.1016/j.molonc.2015.02.011
• Languages: English
• ISSNs: 1574-7891

Abstract

Abstract : Clinical trials are the final links in the chains of knowledge and for determining the roles of therapeutic advances. Unfortunately, in an important sense they are the weakest links. This article describes two designs that are being explored today: platform trials and basket trials. Both are attempting to merge clinical research and clinical practice.