Mitochondrial directed ratiometric fluorescent probe for quantitive detection of sulfur dioxide derivatives. (14th March 2019)

• Record Type: Journal Article
• Authors: Gao, Congcong; Tian, Yong; Zhang, Rubo; Jing, Jing; Zhang, Xiaoling
• Is Part Of: New journal of chemistry. Volume 43:Number 13(2019)
• Page Start: 5255
• Page End: 5259
• Publication Date: 2019-03-14
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj05951a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A good biocompatibility fluorescence probe for imaging of sulfur dioxide derivatives in cancer cells. Abstract : We herein report a ratiometric fluorescent probe, MN, capable of determining SO3 2− /HSO3 − in mitochondria. The probe specifically responds to SO3 2− /HSO3 − and is not interfered with by other biological mercaptans or anions. The LOD of the probe is 85 nM, making it a feasible sensor to image SO3 2− /HSO3 − . With good membrane permeability and low cytotoxicity, MN was successfully used in the ratiometric detection of SO3 2− /HSO3 − in mitochondria.