High thermal stability, pH responsive organogels of 2H-benzo[d]1, 2, 3-triazole derivatives as pharmaceutical crystallization media. Issue 13 (5th December 2018)

• Record Type: Journal Article
• Authors: Torres-Moya, Iván; Saikia, Basanta; Prieto, Pilar; Carrillo, José R.; Steed, Jonathan W.
• Is Part Of: CrystEngComm. Volume 21:Issue 13(2019)
• Page Start: 2135
• Page End: 2143
• Publication Date: 2018-12-05
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/c8ce01742e
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : 2 H -Benzo[ d ]1, 2, 3-triazole derivatives give rise to a supergelator that results in the crystallization of kinetic form I sulfathiazole. Abstract : 2 H -Benzo[ d ]1, 2, 3-triazole derivatives with a range of chemical functionalities showed significant organogel formation, particularly bis-amide derivative4e which gave robust thermally stable gels, in a range of solvents down to 0.1 wt%. The gelators proved responsive under pH stimuli or to the presence of metal cations. The gels also proved to be useful vehicles to crystallize pharmaceutical drugs, resulting in a change in polymorphic outcome in the case of sulfathiazole compared to the solution crystallization outcome.