Co-crystallization and polymorphic behaviour of 5-fluorouracil. Issue 13 (30th November 2018)

• Record Type: Journal Article
• Authors: Enkelmann, Dennis D.; Handelmann, Jens; Schauerte, Carsten; Merz, Klaus
• Is Part Of: CrystEngComm. Volume 21:Issue 13(2019)
• Page Start: 2130
• Page End: 2134
• Publication Date: 2018-11-30
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/c8ce01692e
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : Hydrogen donors and acceptors in 5-fluorouracil allow the formation of co-crystalline compounds with nontoxic co-formers of the GRAS list and an alternative target-oriented synthon approach from methanol or ethanol to form II of 5-fluorouracil is presented. Abstract : Syntheses and single-crystal characterization of two co-crystalline 5-fluorouracil compounds with nontoxic co-formers of the GRAS list, succinic acid and adipic acid, are presented. Furthermore, the target-oriented synthon approach from methanol or ethanol (technical grade) to polymorphic form II, which is hitherto only accessible from dry nitromethane, is described.