Brain activation differences in schizophrenia during context-dependent processing of saccade tasks. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Rodrigue, A.; Austin, B.; Dyckman, K.; McDowell, J.
• Is Part Of: Behavioral and brain functions. Volume 12:Issue 1(2016)
• Page Start: 1
• Page End: 9
• Publication Date: 2016-12
• Subjects: Schizophrenia -- Context -- fMRI -- Antisaccades -- Prosaccades; Neurobiology -- Periodicals; Cognitive neuroscience -- Periodicals; Neurophysiology -- Periodicals; Neuropsychology -- Periodicals; Brain -- Localization of functions -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; 612.8205
• DOI: 10.1186/s12993-016-0103-2
• Languages: English
• ISSNs: 1744-9081

Abstract

Abstract Background Brain function in schizophrenia has been probed using saccade paradigms and functional magnetic resonance imaging, but little information exists about how changing task context impacts saccade related brain activation and behavioral performance. We recruited schizophrenia and comparison subjects to perform saccade tasks in differing contexts: (1) two single task runs (anti- or pro-saccades alternating with fixation) and (2) one dual task run (antisaccades alternating with prosaccades). Results Context-dependent differences in saccade circuitry were evaluated using ROI analyses. Distinction between anti- and pro-saccade activation across contexts (single versus dual task) suggests that the schizophrenia group did not respond to context in the same way as the comparison group. Conclusions Further investigation of context processing effects on brain activation and saccade performance measures informs models of cognitive deficits in the disorder and enhances understanding of antisaccades as a potential endophenotype for schizophrenia.