Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Ajarem, Jamaan; Altoom, Naif; Allam, Ahmed; Maodaa, Saleh; Abdel- Maksoud, Mostafa; Chow, Billy
• Is Part Of: Behavioral and brain functions. Volume 12:Issue 1(2016)
• Page Start: 1
• Page End: 10
• Publication Date: 2016-12
• Subjects: Organ toxicity -- Dopamine -- Serotonin -- Acetylcholine -- Reduced glutathione; Neurobiology -- Periodicals; Cognitive neuroscience -- Periodicals; Neurophysiology -- Periodicals; Neuropsychology -- Periodicals; Brain -- Localization of functions -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; 612.8205
• DOI: 10.1186/s12993-016-0098-8
• Languages: English
• ISSNs: 1744-9081

Abstract

Abstract Background Potassium bromate (KBrO3 ) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO3 administration on the brain functions and behaviour of albino mice. Methods Animals were divided into three groups: control, low dose KBrO3 (100 mg/kg/day) and high dose KBrO3 (200 mg/kg/day) groups. Results Administration of KBrO3 led to a significant change in the body weight in the animals of the high dose group in the first, second and the last weeks while water consumption was not significantly changed. Neurobehavioral changes and a reduced Neurotransmitters levels were observed in both KBrO3 groups of mice. Also, the brain level of reduced glutathione (GSH) in KBrO3 receiving animals was decreased. Histological studies favoured these biochemical results showing extensive damage in the histological sections of brain of KBrO3 -treated animals. Conclusions These results show that KBrO3 has serious damaging effects on the central nervous system and therefore, its use should be avoided.