A General and Practical Approach for the Synthesis of 1, 2, 4‐Trioxanes Catalyzed by Silica‐Ferric Chloride. Issue 20 (6th September 2017)

• Record Type: Journal Article
• Authors: Zhang, Mo; Han, Yi; Niu, Jia‐Liang; Zhang, Zhan‐Hui
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 20(2017)
• Page Start: 3618
• Page End: 3625
• Publication Date: 2017-09-06
• Subjects: carbonyl compounds -- β-hydroperoxy alcohols -- silica-supported iron(III) chloride -- 1, 2, 4-trioxanes; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201700671
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An efficient and practical method has been developed for the facile synthesis of 1, 2, 4‐trioxanes by the condensation of β‐hydroperoxy alcohols and carbonyl compounds in the presence of a catalytic amount of silica‐supported ferric chloride (FeCl3 /SiO2 ) at room temperature. The method has the benefits of operational simplicity, high yields and potential large‐scale application. Moreover, the catalyst can be readily recovered by simple filtration and reused up to five times while almost maintaining its catalytic activity. Abstract :