Essential functions linked with structural disorder in organisms of minimal genome. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Pancsa, Rita; Tompa, Peter
• Is Part Of: Biology direct. Volume 11:Issue 1(2016)
• Page Start: 1
• Page End: 10
• Publication Date: 2016-12
• Subjects: Intrinsically disordered -- Structural disorder -- Genome reduction -- Endosymbiont -- Minimal genome -- Disorder prediction -- Essential function -- Genome-reduced bacterium -- Chaperone function; Biology -- Periodicals; 570.5
• DOI: 10.1186/s13062-016-0149-y
• Languages: English
• ISSNs: 1745-6150

Abstract

Abstract Intrinsically disordered regions (IDRs) of proteins fulfill important regulatory roles in most organisms. However, the proteins of certain endosymbiont and intracellular pathogenic bacteria with extremely reduced genomes contain disproportionately small amounts of IDRs, consisting almost entirely of folded domains. As their genomes co-evolving with their hosts have been reduced in unrelated lineages, the proteomes of these bacteria represent independently evolved minimal protein sets. We systematically analyzed structural disorder in a representative set of such minimal organisms to see which types of functionally relevant longer IDRs are invariably retained in them. We found that a few characteristic functions are consistently linked with conformational disorder: ribosomal proteins, key components of the protein production machinery, a central coordinator of DNA metabolism and certain housekeeping chaperones seem to strictly rely on structural disorder even in genome-reduced organisms. We propose that these functions correspond to the most essential and probably also the most ancient ones fulfilled by structural disorder in cellular organisms. Reviewers This article was reviewed by Michael Gromiha, Zoltan Gaspari and Sandor Pongor.