Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Kinoshita, Shinya; Kanazawa, Tetsufumi; Kikuyama, Hiroki; Yoneda, Hiroshi
• Is Part Of: Behavioral and brain functions. Volume 12:Issue 1(2016)
• Page Start: 1
• Page End: 8
• Publication Date: 2016-12
• Subjects: DEX/CRH test -- NIRS -- Depression -- Biomarker -- HAMD; Neurobiology -- Periodicals; Cognitive neuroscience -- Periodicals; Neurophysiology -- Periodicals; Neuropsychology -- Periodicals; Brain -- Localization of functions -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; 612.8205
• DOI: 10.1186/s12993-016-0108-x
• Languages: English
• ISSNs: 1744-9081

Abstract

Abstract Background To reduce the number of patients with depression, biomarkers for clarifying psychiatric disorders are warranted. Numerous candidates have been proposed; however, near-infrared spectroscopy (NIRS) with multi-channel probes and a dexamethasone/corticotropin-releasing hormone (DEX/CRH) test are still surviving for practical demand. Thirty-one outpatients with depressed moods were analyzed using both biological tests. Results The non-suppressors, as indicated by the DEX/CRH test, exhibited a high severity on the Hamilton Depression Scale and severe anxiety on the State Trait Anxiety Scale. In addition, a unique response was identified via NIRS in the same group suggested by the DEX/CRH assessment. Conclusions The results obtained from these biological tests did not fit well with the category defined by operative diagnostic criteria, such as the Diagnostic and StatisticalManual of Mental Disorders or The International Classification of Diseases. Thus, it is critical that the utility evaluations of candidate biomarkers not be assessed by comparisons with the categorized criteria for a specific psychiatric disorder. Trial registration UMIN000013214, Registered 21 February 2014