Pre-blocked molecular shuttle as an in-situ real-time theranostics. (June 2019)

• Record Type: Journal Article
• Authors: Sun, Tao; Zhang, Guangping; Wang, Qingbing; Guo, Zhongyuan; Chen, Qinjun; Chen, Xinli; Lu, Yifei; Zhang, Yu; Zhang, Yujie; Guo, Qin; Gao, Xiang; Cheng, Yongzhong; Jiang, Chen
• Is Part Of: Biomaterials. Volume 204(2019)
• Page Start: 46
• Page End: 58
• Publication Date: 2019-06
• Subjects: Theranostics -- Molecular shuttle -- Real-time monitoring -- Molecular recognition -- Oxaliplatin; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2019.02.019
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Real-time monitor of drug-release from drug formulations in a noninvasive way can provide spatio-temporal information for drug activation and guide further clinical rational administration. In this work, a molecular shuttle, as a typical nanosized artificial molecular machine, was managed to act as a conceptually-new nanotheranostics for oxaliplatin. A post-recognition strategy was utilized, where a default supramolecular-dye couple was pre-blocked. The rational design, synthesis, characterization and proof-of-concept of this strategy were described in detail. The drug-release upon reducing environment can be translated into near-infrared (NIR) fluorescence signal (OFF-to-ON), allowing to track the drug-release procedure by multi-modal images including IVIS, FLECT and photoacoustic imaging. The versatile nanotheranostics system can target to triple negative breast tumor via conjugated F3 peptide, and show an improved anti-tumor efficacy with much lower side effect. The intelligent nanotheranostics system based on molecular shuttle provides new reference for precision medicine in preclinical trial and postclinical evaluation.