Amphiphilic carboxylated cellulose-g-poly(l-lactide) copolymer nanoparticles for oleanolic acid delivery. (15th June 2019)

• Record Type: Journal Article
• Authors: Wang, Yingsa; Zhu, Pengbo; Li, Guiliang; Zhu, Shangbin; Liu, Kefeng; Liu, Yanxue; He, Jing; Lei, Jiandu
• Is Part Of: Carbohydrate polymers. Volume 214(2019)
• Page Start: 100
• Page End: 109
• Publication Date: 2019-06-15
• Subjects: Carboxylated cellulose nanocrystals -- Amphiphilic copolymer -- Nanoparticles -- Oleanolic acid -- Drug delivery; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2019.03.033
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Carboxylated cellulose-g-poly(l -lactide) copolymers were synthesized. The amphiphilic copolymers improved the organic solubility of CCNs. The copolymers were self-assembled into nanoparticles for oleanolic acid delivery. The nanoparticles improved the drug solubility and prolonged the drug release. The nanoparticles maintained the cell inhibition and enhanced antitumor efficiency. Abstract: Carboxylated cellulose nanocrystals (CCNs), as one of nanocellulose are promising hydrophilic biomass materials for drug delivery. In this work, a series of amphiphilic carboxylated cellulose-graft-Poly(L-lactide) (CC-g-PLLA) copolymers were synthesized via ring-opening polymerization (ROP) method. The copolymers were characterized by 1 H-NMR, FT-IR, WXRD and TGA, and their solubility in organic solvents was improved. Then, these amphiphilic copolymers were self-assembled into nanoparticles for delivery of anticancer drug oleanolic acid (OA). The copolymer (DSPLLA 2.03) nanoparticles displayed the smallest size (196.82 ± 9.14 nm) and the highest drug loading efficiency (24.76 ± 0.58%). The nanoparticles exhibited a spherical shape, well water solubility of OA (16.9 mg/mL) and a prolonged drug release (120 h). In vitro and In vivo study indicated that the nanoparticles maintained cytotoxicity to 4T1 cells and MCF-7 cells and displayed high antitumor efficiency. The amphiphilic CC-g-PLLA copolymer nanoparticles provide a novel platform for drug delivery.