Allylated chitosan-poly(N-isopropylacrylamide) hydrogel based on a functionalized double network for controlled drug release. (15th June 2019)

• Record Type: Journal Article
• Authors: Xu, Shouping; Li, Hao; Ding, Huan; Fan, Zhouxiang; Pi, Pihui; Cheng, Jiang; Wen, Xiufang
• Is Part Of: Carbohydrate polymers. Volume 214(2019)
• Page Start: 8
• Page End: 14
• Publication Date: 2019-06-15
• Subjects: Allylated chitosan -- Double network hydrogel -- pH-sensitive -- Schiff base bond; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2019.03.008
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: Smart double network hydrogels with molecular switch were prepared. The switch could obviously protect the loaded drug in simulated intestinal fluid. The switch opened in acidic solution could improve the release efficiency markedly. The double network hydrogel is expected to be used as a novel drug carrier. Abstract: Smart hydrogels with dual network were presented since a new allylated chitosan was conceived. As a double network hydrogel, its first network consisted of poly( N -isopropylacrylamide) worked as the gel matrix, and its second network with Schiff base bond enabled itself function as a molecular switch through the formation and break of the bond. When only the intestinal fluid was used, the second network could provide efficient protection for the loaded drug, and the drug release mechanism conformed to the non-Fickian type diffusion. While pre-treated with simulated gastric fluid, the switch would be opened and the mechanism was the Fickian type, which increased the cumulative percentage of drug release by about 25% and the release time by about 300 min. Besides, the hydrogel was characterized by 1 H NMR, FT-IR and SEM. The effects of allylated chitosan, pH and crosslinker on the swelling ratio and morphology of hydrogel were also studied.