Reoxygenation during radiotherapy in intermediate-risk prostate cancer. (April 2019)

• Record Type: Journal Article
• Authors: Supiot, Stéphane; Rousseau, Caroline; Dore, Mélanie; Chèze-Le-Rest, Catherine; Kandel-Aznar, Christine; Potiron, Vincent; Guerif, Stéphane; Paris, François; Ferrer, Ludovic; Campion, Loïc; Meingan, Philippe; Delpon, Grégory; Hatt, Mathieu; Visvikis, Dimitris
• Is Part Of: Radiotherapy and oncology. Volume 133(2019)
• Page Start: 16
• Page End: 19
• Publication Date: 2019-04
• Subjects: Dose painting radiotherapy -- Radioresistance -- Misonidazole -- FAZA -- IMRT; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2018.12.022
• Languages: English
• ISSNs: 0167-8140

Abstract

Abstract: Hypoxia is a major risk factor of prostate cancer radioresistance. We evaluated hypoxia non-invasively, using 18 F-Misonidazole PET/CT prior to radiotherapy and after a dose of 20 Gy in intermediate-risk prostate cancer patients. Decreased hypoxic volumes were observed in all patients, suggesting that radiotherapy induces early prostate tumor reoxygenation.