Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Mandal, Jyotshna; Malla, Bijaya; Steffensen, Rudi; Costa, Luigi; Egli, Adrian; Trendelenburg, Marten; Blasi, Francesco; Kostikas, Kostantinos; Welte, Tobias; Torres, Antoni; Louis, Renaud; Boersma, Wim; Milenkovic, Branislava; Aerts, Joachim; Rohde, Gernot; Lacoma, Alicia; Rentsch, Katharina; Roth, Michael; Tamm, Michael; Stolz, Daiana
• Is Part Of: Respiratory research. Volume 16:Issue 1(2015)
• Page Start: 1
• Page End: 9
• Publication Date: 2015-12
• Subjects: Lung function -- Haplotypes -- Exacerbation -- Survival rate; Respiratory organs -- Diseases -- Periodicals; 616.2005
• DOI: 10.1186/s12931-015-0306-3
• Languages: English
• ISSNs: 1465-993X

Abstract

Abstract Background Functional deficiency of mannose-binding lectin (MBL) may contribute to the pathogenesis of chronic obstructive pulmonary disease. We hypothesized that specific MBL2 gene polymorphisms and circulating MBL protein levels are associated with clinically relevant outcomes in the Predicting Outcome using systemic Markers In Severe Exacerbations of COPD PROMISE-COPD cohort. Methods We followed 277 patients with stable COPD GOLD stage II-IV COPD over a median period of 733 days (IQR 641–767) taking survival as the primary outcome parameter. Patients were dichotomized as frequent (≥2 AECOPD/year) or infrequent exacerbators. Serum MBL levels and single nucleotide polymorphisms of the MBL2 gene were assessed at baseline. Results TheMBL2-HYPD haplotype was significantly more prevalent in frequent exacerbators (OR: 3.33; 95 % CI, 1.24–7.14, p = 0.01). The median serum MBL concentration was similar in frequent (607 ng/ml, [IQR; 363.0–896.0 ng/ml]) and infrequent exacerbators (615 ng/ml, [IQR; 371.0–942.0 ng/ml]). Serum MBL was not associated with lung function characteristics or bacterial colonization in sputum. However, high serum MBL at stable state was associated with better survival compared to low MBL (p = 0.046, log rank test). Conclusions In COPD, theHYPD haplotype ofMBL2 gene is associated with frequent exacerbations and high serum MBL is linked to increased survival. The PROMISE-COPD study was registered atwww.controlled-trials.com under the identifierISRCTN99586989 .