Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Liu, Hao; Mao, Ping; Xie, Changhou; Xie, Wanfu; Wang, Maode; Jiang, Haitao
• Is Part Of: BMC neurology. Volume 16:Issue 1(2016)
• Page Start: 1
• Page End: 6
• Publication Date: 2016-12
• Subjects: Apolipoprotein E -- Gene polymorphism -- Intracranial aneurysms; Neurology -- Periodicals; 616.8005
• DOI: 10.1186/s12883-016-0537-z
• Languages: English
• ISSNs: 1471-2377

Abstract

Abstract Background The relationship between the apolipoprotein E (APOE ) polymorphism and intracranial aneurysms has previously only been studied in Russia and Japan but not in Chinese populations. The purpose of this study was to investigate the association betweenAPOE polymorphism and the risk of intracranial aneurysms in a Chinese population. Methods The study population consisted of 150 intracranial aneurysms patients and 150 matched control subjects. TheAPOE gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results Patients with intracranial aneurysms had a significantly higher frequency ofAPOE E2/E2 genotype [odds ratio (OR) =9.51, 95 % confidence interval (CI) = 1.19, 76.04;P = 0.03] andAPOE E2/E3 genotype (OR = 1.87, 95 % CI = 1.03, 3.40;P = 0.04) than healthy controls. TheAPOE E4/E4 genotype frequencies (OR = 0.09, 95 % CI = 0.01, 0.74;P = 0.03) in the intracranial aneurysms group were significantly lower than those in the controls group. When stratified by the site, shape, size and the Fisher Grade of intracranial aneurysms, no statistically significant result was observed. Conclusion Our study suggested thatAPOE polymorphism might be associated with intracranial aneurysms in Chinese population. Additional studies are needed to confirm this finding.