Dynamic Biointerfaces: From Recognition to Function. Issue 9 (29th October 2014)

• Record Type: Journal Article
• Authors: Chang, Baisong; Zhang, Mingxi; Qing, Guangyan; Sun, Taolei
• Is Part Of: Small. Volume 11:Issue 9/10(2015)
• Page Start: 1097
• Page End: 1112
• Publication Date: 2014-10-29
• Subjects: dynamic biointerfaces -- biointerfaces -- chirality -- H‐bonding interactions -- molecular recognition -- biological functions; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201402038
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : The transformation of recognition signals into regulating macroscopic behaviors of biological entities (e.g., biomolecules and cells) is an extraordinarily challenging task in engineering interfacial properties of artificial materials. Recently, there has been extensive research for dynamic biointerfaces driven by biomimetic techniques. Weak interactions and chirality are two crucial routes that nature uses to achieve its functions, including protein folding, the DNA double helix, phospholipid membranes, photosystems, and shell and tooth growths. Learning from nature inspires us to design dynamic biointerfaces, which usually take advantage of highly selective weak interactions (e.g., synergetic chiral H‐bonding interactions) to tailor their molecular assemblies on external stimuli. Biomolecules can induce the conformational transitions of dynamic biointerfaces, then drive a switching of surface characteristics (topographic structure, wettability, etc.), and eventually achieve macroscopic functions. The emerging progresses of dynamic biointerfaces are reviewed and its role from molecular recognitions to biological functions highlighted. Finally, a discussion is presented of the integration of dynamic biointerfaces with the basic biochemical processes, possibly solving the big challenges in life science. Abstract : A dynamic biointerface based on synergetic chiral H‐bonding interactions can transform weak signals of molecular or chiral recognitions into changes of the macroscopic behaviors of cells and biomolecules, which can break the limitation of conventional polymers and has the ability to solve the big challenges in life sciences.