Applying computation biology and "big data" to develop multiplex diagnostics for complex chronic diseases such as osteoarthritis. (17th November 2015)

• Record Type: Journal Article
• Authors: Ren, Guomin; Krawetz, Roman
• Is Part Of: Biomarkers. Volume 20:Number 8(2015)
• Page Start: 533
• Page End: 539
• Publication Date: 2015-11-17
• Subjects: Chronic disease -- computational biology -- diagnostics -- osteoarthritis; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2015.1105499
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: The data explosion in the last decade is revolutionizing diagnostics research and the healthcare industry, offering both opportunities and challenges. These high-throughput "omics" techniques have generated more scientific data in the last few years than in the entire history of mankind. Here we present a brief summary of how "big data" have influenced early diagnosis of complex diseases. We will also review some of the most commonly used "omics" techniques and their applications in diagnostics. Finally, we will discuss the issues brought by these new techniques when translating laboratory discoveries to clinical practice.