Insulin resistance and β-cell function influence postprandial blood glucose levels in Japanese patients with gestational diabetes mellitus. (2nd December 2015)

• Record Type: Journal Article
• Authors: Kusunoki, Yoshiki; Katsuno, Tomoyuki; Nakae, Rie; Watanabe, Kahori; Ochi, Fumihiro; Tokuda, Masaru; Akagami, Takafumi; Miuchi, Masayuki; Miyagawa, Jun-ichiro; Namba, Mitsuyoshi
• Is Part Of: Gynecological endocrinology. Volume 31:Number 12(2015:Dec.)
• Page Start: 929
• Page End: 933
• Publication Date: 2015-12-02
• Subjects: β-Cell function -- continuous glucose monitoring -- gestational diabetes mellitus -- insulin resistance -- 75 g oral glucose tolerance test; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2015.1075498
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Aims/introduction : The aim of this study in patients with gestational diabetes mellitus (GDM) was to evaluate the relationship of insulin resistance and secretion to area-under-the-sensor glucose concentration–time curve from before to 120 min postmeal (CGM-AUC0–120 min ) as determined with continuous glucose monitoring (CGM). Materials and methods : Immunoreactive insulin and HbA1c were determined in 22 Japanese patients with GDM undergoing a 75 g oral glucose tolerance test. Patients underwent CGM within 3 weeks of receiving a diagnosis of GDM. Results : HbA1c (NGSP) was 5.5 ± 0.4%, BMI was 24.8 ± 5.3 kg/m 2, mean sensor glucose by CGM was 94.2 ± 10.3 mg/dL, standard deviation was 17.5 ± 4.4 mg/dL, and CGM-AUC0–120 min was 204.2 ± 23.8 h mg/dL. The insulin resistance indices the homeostasis model assessment ratio (HOMA-R), quantitative insulin sensitivity check index (QUICKI), and the Matsuda Index were correlated with CGM-AUC0–120 min . The disposition index (DI), which was used to evaluate insulin secretion, was negatively correlated with CGM-AUC0–120 min . Conclusions : Not only insulin resistance but also beta cell dysfunction contributes to postprandial hyperglycemia in Japanese patients with GDM.