A protease inhibition strategy based on acceleration of autolysis. Issue 27 (4th March 2015)

• Record Type: Journal Article
• Authors: Lv, Yan; Zhang, Jianbin; Wu, Hao; Zhao, Shan; Song, Yizhe; Wang, Shujun; Wang, Bing; Lv, Guojun; Ma, Xiaojun
• Is Part Of: Chemical communications. Volume 51:Issue 27(2015)
• Page Start: 5959
• Page End: 5962
• Publication Date: 2015-03-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc01448d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An iconoclastic protease inhibition strategy based on autolysis acceleration: proteases are concentrated and induced to self-digest by a polymer via electrostatic interaction. Such a catalytic cycle results in high inhibition efficiency. Abstract : We report on an iconoclastic strategy for inhibiting proteases via autolysis acceleration. We show that proteases can be concentrated and induced to rapidly self-digest by a biocompatible polymer serving as an efficient catalyst. This new generation of protease inhibitors may find applications in the treatment of various protease-dependent diseases.