Liquid carbon dioxide as an effective solvent for immobilized Candida antarctica lipase B catalyzed transesterification. Issue 4 (21st January 2015)

• Record Type: Journal Article
• Authors: Hoang, Hai Nam; Matsuda, Tomoko
• Is Part Of: Tetrahedron letters. Volume 56:Issue 4(2015)
• Page Start: 639
• Page End: 641
• Publication Date: 2015-01-21
• Subjects: Liquid carbon dioxide -- Asymmetric synthesis -- Candida antarctica lipase B -- Transesterification; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2014.12.080
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: The transesterification of alcohols catalyzed by immobilized Candida antarctica lipase B (Novozym 435®) was found to be effectively enhanced using a liquid CO2 medium when it was compared with that using organic solvents. The large-scale kinetic-resolution of secondary alcohol by the immobilized lipase was also successfully performed with a continuous packed-column reactor that stably afforded corresponding enantiopure products. Herein, liquid CO2 was proved for the first time to be superior to conventional organic solvents for biotransformation.