Β-Glucan exacerbates allergic airway responses to house dust mite allergen. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Hadebe, Sabelo; Kirstein, Frank; Fierens, Kaat; Redelinghuys, Pierre; Murray, Graeme; Williams, David; Lambrecht, Bart; Brombacher, Frank; Brown, Gordon
• Is Part Of: Respiratory research. Volume 17:Issue 1(2016)
• Page Start: 1
• Page End: 3
• Publication Date: 2016-12
• Subjects: β-glucans -- Allergy -- Eosinophil -- T helper 2 -- House dust mite; Respiratory organs -- Diseases -- Periodicals; 616.2005
• DOI: 10.1186/s12931-016-0352-5
• Languages: English
• ISSNs: 1465-993X

Abstract

Abstract β-(1, 3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.