Is caffeine intake a risk factor leading to infertility? A protocol of an epidemiological systematic review of controlled clinical studies. Issue 1 (December 2016)
- Record Type:
- Journal Article
- Title:
- Is caffeine intake a risk factor leading to infertility? A protocol of an epidemiological systematic review of controlled clinical studies. Issue 1 (December 2016)
- Main Title:
- Is caffeine intake a risk factor leading to infertility? A protocol of an epidemiological systematic review of controlled clinical studies
- Authors:
- Cao, Huijuan
Ren, Jun
Feng, Xue
Yang, Guoyan
Liu, Jianping - Abstract:
- Abstract Background Previous studies showed that high dose of caffeine intake may induce some specific human reproductive system diseases, even lead to infertility. Objectives In consideration of the high consumption of caffeine according to the latest population-based survey, this review is aimed to systematically review the evidence from all controlled clinical studies of caffeine intake for infertility. Designs Relevant randomized/quasi-randomized controlled trials, non-randomized clinical studies, cohort studies, and case-control studies will be included in this review. Participants will be either those without a history of infertility who are willing to have a baby (for prospective studies) or infertile patients with confirmed diagnosis (for retrospective studies). Caffeine or caffeine-containing beverage will be observed as the exposure factor. The key outcome will be the diagnosis of infertility in participants. All relevant published/unpublished or ongoing studies will be searched from seven databases and four online systems until December 2015. Two authors will screen the literatures and extract the data independently. Methodological quality of the included studies will be assessed by two authors according to either Risk of Bias Assessment or Newcastle-Ottawa Scale. We will use R software to analyze the data. Dose of caffeine will be quantified on a daily basis, and relative risk with their 95 % confidence interval will be measured. If data permit, meta-analysis andAbstract Background Previous studies showed that high dose of caffeine intake may induce some specific human reproductive system diseases, even lead to infertility. Objectives In consideration of the high consumption of caffeine according to the latest population-based survey, this review is aimed to systematically review the evidence from all controlled clinical studies of caffeine intake for infertility. Designs Relevant randomized/quasi-randomized controlled trials, non-randomized clinical studies, cohort studies, and case-control studies will be included in this review. Participants will be either those without a history of infertility who are willing to have a baby (for prospective studies) or infertile patients with confirmed diagnosis (for retrospective studies). Caffeine or caffeine-containing beverage will be observed as the exposure factor. The key outcome will be the diagnosis of infertility in participants. All relevant published/unpublished or ongoing studies will be searched from seven databases and four online systems until December 2015. Two authors will screen the literatures and extract the data independently. Methodological quality of the included studies will be assessed by two authors according to either Risk of Bias Assessment or Newcastle-Ottawa Scale. We will use R software to analyze the data. Dose of caffeine will be quantified on a daily basis, and relative risk with their 95 % confidence interval will be measured. If data permit, meta-analysis and dose-response analysis will be conducted. Summary of findings tables will be generated using Guideline Development Tool online. Systematic review registration PROSPEROCRD42015015714 … (more)
- Is Part Of:
- Systematic reviews. Volume 5:Issue 1(2016)
- Journal:
- Systematic reviews
- Issue:
- Volume 5:Issue 1(2016)
- Issue Display:
- Volume 5, Issue 1 (2016)
- Year:
- 2016
- Volume:
- 5
- Issue:
- 1
- Issue Sort Value:
- 2016-0005-0001-0000
- Page Start:
- 1
- Page End:
- 6
- Publication Date:
- 2016-12
- Subjects:
- Caffeine intake -- Infertility -- Systematic review
Systematic reviews (Medical research) -- Periodicals
616.0072 - Journal URLs:
- http://www.systematicreviewsjournal.com/ ↗
http://link.springer.com/ ↗ - DOI:
- 10.1186/s13643-016-0221-9 ↗
- Languages:
- English
- ISSNs:
- 2046-4053
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 9908.xml