Genetic diversity of Plasmodium falciparum isolates from Baka Pygmies and their Bantu neighbours in the north of Gabon. (December 2015)

• Record Type: Journal Article
• Authors: Mvé-Ondo, Bertrand; Nkoghe, Dieudonné; Arnathau, Céline; Rougeron, Virginie; Bisvigou, Ulrich; Mouele, Lauriane; Boundenga, Larson; Durand, Patrick; Elguero, Eric; Lemmers, Simone; Délicat-Loembet, Lucrèce; Diamella-Moukodoum, Nancy; Paupy, Christophe; Renaud, François; Prugnolle, Franck; Ollomo, Benjamin
• Is Part Of: Malaria journal. Volume 14:Number 1(2015)
• Page Start: 1
• Page End: 11
• Publication Date: 2015-12
• Subjects: Malaria -- Genetic diversity -- Population structure -- Microsatellite loci -- Antigenic determinants -- Baka Pygmies -- Bantus; Malaria -- Periodicals; 616.9362
• DOI: 10.1186/s12936-015-0862-5
• Languages: English
• ISSNs: 1475-2875

Abstract

Abstract Background There have been many reports on the population genetic structure ofPlasmodium falciparum from different endemic regions especially sub-Saharan Africa. However, few studies have been performed on neglected populations, such as the Pygmy populations. In this study, the population genetic structure ofP. falciparum was investigated in the Baka Pygmies of Gabon and compared to that observed in neighboring villages composed mostly of Bantu farmers. Methods A total of 342 blood samples were collected from 170 Baka Pygmies and 172 Bantus in the north of Gabon (Woleu Ntem Province).Plasmodium infections were characterized by sequencing a portion of the parasitecytochrome b gene. Population genetic structure ofP. falciparum in the different villages was analysed using microsatellite markers and genes coding for antigenic proteins (MSP1, MSP2, GLURP, and EBA-175). Results Overall, prevalence ofP. falciparum was around 57 % and no significant difference of prevalence was observed between Pygmies and Bantus. No significant differences of population genetic structure ofP. falciparum was found between Pygmy and Bantu people except for one antigen-coding gene, glurp, for which genetic data suggested the existence of a potentially disruptive selection acting on this gene in the two types of populations. The genetic structure ofP. falciparum followed a pattern of isolation by distance at the scale of the study. Conclusion The prevalence and genetic diversity ofP. falciparum observed in Baka demonstrates a significant transmission of the parasite in this population, and some exchanges of parasites with Bantu neighbours. Despite that, some antigen-coding genes seem to have had a particular evolutionary trajectory in certain Pygmy populations due to specific local human and/or mosquito characteristics.