Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Li, Xia; Luo, Jun-Yi; Zhang, Lei; Yang, Yi-Ning; Xie, Xiang; Liu, Fen; Chen, Bang-Dang; Ma, Yi-Tong
• Is Part Of: Lipids in health and disease. Volume 14:Issue 1(2015)
• Page Start: 1
• Page End: 6
• Publication Date: 2015-12
• Subjects: PAI-2 gene -- Polymorphism -- Coronary artery disease -- Recurrent coronary event risk; Lipids -- Periodicals; Lipids in human nutrition -- Periodicals; Lipids -- Metabolism -- Disorders -- Periodicals; 616.3997
• DOI: 10.1186/s12944-015-0150-y
• Languages: English
• ISSNs: 1476-511X

Abstract

Abstract Background Plasminogen activator inhibitor −2 (PAI-2) is an important molecular that plays a crucial role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD). Methods The aim of the current study was to explore the association between the variants inPAI-2 gene and CAD and its prognoses. The three variants (rs8093048, rs9946657, rs9320032) of thePAI-2 gene were detected in 407 patients with CAD and 518 control subjects. All patients with CAD underwent one-year follow-up for major adverse cardiac events (MACE). Results The frequencies of the TT genotype and T allele of rs8093048 was significantly higher in CAD patients than that in control subjects (7.6 % vs.3.5 %, P = 0.003, 28.1 % vs.21.7 %, P < 0.001, respectively). Multifactor logistic regression analysis showed that the TT genotype of rs8093048 was a risk factor for CAD (OR = 1.455, 95 % CI: 1.069-1.980, P = 0.017). In addition, the follow-up data showed that CAD patients with rs8093048 TT genotype had significantly higher rate of refractory angina and MACE than those with CC or CT genotype (P = 0.032, P = 0.009, respectively). Cox regression analysis showed that rs8093048 TT genotype was the risk factor for the MACE (Hazard ratio = 5.672, 95 % CI = 1.992-16.152, P = 0.001). Conclusion We firstly found that the variant ofPAI-2 gene was associated with CAD and recurrent coronary event risk in Chinese Han population, in Xinjiang.