Intraoperative infusion of branched-chain amino acids in patients undergoing gastrointestinal tumor surgery. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Wu, Qiwei; Zhang, Yanying; Yang, Yan; Ge, Shengjin; Xue, Zhanggang
• Is Part Of: World journal of surgical oncology. Volume 13:Issue 1(2015)
• Page Start: 1
• Page End: 6
• Publication Date: 2015-12
• Subjects: Metabolism-glucose -- Metabolism-lipid -- Temperature-metabolism; Cancer -- Surgery -- Periodicals; Tumors -- Periodicals; Tumors -- Surgery -- Periodicals; Surgery, Operative -- Periodicals; 616.994059
• DOI: 10.1186/s12957-015-0751-y
• Languages: English
• ISSNs: 1477-7819

Abstract

Abstract Background The purpose of this study is to investigate the effects of intraoperative infusion of branched-chain amino acids (BCAA) in patients undergoing gastrointestinal tumor surgery. Methods Sixty-one patients with gastrointestinal tumors undergoing gastrointestinal surgery were enrolled and randomly assigned to receive an intraoperative infusion of 3-compound BCAA solution (N = 20), amino acids (AA) solution (N = 21), or normal saline (NS) (N = 20). Nasopharyngeal temperature, blood glucose (BG), plasma insulin, and blood free fatty acids (FFA) concentrations were measured at 30 min before and 10 min after induction (T 0, T 1 ), 30 min and 2 h after skin incision (T 2, T 3 ), and 1 h after tracheal extubation (T 4 ). Intensity of shivering and pain was accessed at 1 h after extubation. Results The temperature in the BCAA and AA group was significantly higher than that in the NS group atT 4 (P = 0.014 and 0.033). The incidence of shivering in the BCAA and AA group was significantly lower than in the NS group (P = 0.027 and 0.012). BG increased in AA group atT 3 andT 4 (P = 0.001 and 0.045). The plasma insulin concentration increased in the BCAA and AA group fromT 1 toT 3 . The plasma FFA concentrations in the BCAA group were lower than in the AA and NS group fromT 2 toT 4 . Conclusions Intraoperative BCAA and AA infusion alleviated postoperative hypothermia and shivering. BCAA infusion also inhibited fat mobilization, without adversely affecting blood glucose. Trial registration ChiCTR-TRC-14004668