Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Yiallouros, Panayiotis; Kouis, Panayiotis; Kolokotroni, Ourania; Youhanna, Sonia; Savva, Savvas; Dima, Kleanthi; Zerva, Aikaterini; Platt, Danielle; Middleton, Nicos; Zalloua, Pierre
• Is Part Of: Italian journal of pediatrics. Volume 42:Issue 1(2016)
• Page Start: 1
• Page End: 9
• Publication Date: 2016-12
• Subjects: Asthma -- Children -- High density lipoprotein cholesterol -- Polymorphisms -- Genotypes; Pediatrics -- Periodicals; 618.920005
• DOI: 10.1186/s13052-016-0276-1
• Languages: English
• ISSNs: 1824-7288

Abstract

Abstract Background In a cohort of children in Cyprus, we recently reported low levels of high density lipoprotein cholesterol (HDL-C) to be associated with asthma. We examined whether genetic polymorphisms that were previously linked individually to asthma, obesity, or HDL-C are associated with both asthma and HDL-C levels in the Cyprus cohort. Methods We assessed genotypes frequencies in current-wheezers (n = 190) and non-asthmatic controls (n = 671) and HDL-C levels across several genotypes. Binary logistic regression models were used to assess the effect of genotypes on wheezing risk and examined whether this effect is carried out through changes of HDL–C. Results Of the 16 polymorphisms tested, two polymorphismsTNFa rs3093664 andPRKCA rs9892651 presented significant differences in genotype distribution among current-wheezers and controls. Higher HDL-C levels were noted in carriers of genotype GG of polymorphismTNFa rs3093664 that was protective for wheezing Vs AG and AA genotypes (65.3 Vs 51.8 and 53.3 mg/dl, p -value < 0.001 andp -value for trend = 0.028). In polymorphismPRKCA rs9892651, HDL-C levels were lower in carriers of CC and TC genotypes that were more frequent in current-wheezers Vs TT genotype (52.2 and 52.7 Vs 55.2 mg/dl, p -value = 0.042 andp -value for trend = 0.02). The association ofTNFa rs3093664 with wheezing is partly mediated by its effect on HDL-C whereas association ofPRKCA rs9892651 with wheezing appeared to be independent of HDL-C. Conclusions We found evidence that two SNPs located in different genetic loci, are associated with both wheezing and HDL-C levels, although more studies in other populations are needed to confirm our results.