Trends in paediatric and adult bloodstream infections at a Ghanaian referral hospital: a retrospective study. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Obeng-Nkrumah, Noah; Labi, Appiah-Korang; Addison, Naa; Labi, Juliana; Awuah-Mensah, Georgina
• Is Part Of: Annals of clinical microbiology and antimicrobials. Volume 15:Issue 1(2016)
• Page Start: 1
• Page End: 10
• Publication Date: 2016-12
• Subjects: Ghana -- Bloodstream -- Infections -- Infants -- Adults -- Antibiotic susceptibility; Medical microbiology -- Periodicals; Anti-infective agents -- Periodicals; 616.9041
• DOI: 10.1186/s12941-016-0163-z
• Languages: English
• ISSNs: 1476-0711

Abstract

Abstract Background Bloodstream infections (BSI) are life-threatening emergencies. Identification of the common pathogens and their susceptibility patterns is necessary for timely empirical intervention. Methods We conducted a 4-year retrospective analysis of blood cultures from all patients excluding neonates at the Korle-Bu Teaching hospital, Ghana, from January 2010 through December 2013. Laboratory report data were used to determine BSI, blood culture contamination, pathogen profile, and antimicrobial resistance patterns. Results Overall, 3633 (23.16 %) out of 15, 683 blood cultures were positive for various organisms. Pathogen-positive cultures accounted for 1451 (9.3 %, 95 % CI 8.5–9.8 %). Infants recorded the highest true blood culture positivity (20.9 %, n = 226/1083), followed by the elderly (13.3 %, n = 80/601), children (8.9 %, n = 708/8000) and adults (7.2 %, n = 437/6000) (p = 0.001 for Marascuilo's post hoc). Overall occurrence of BSI declined with increasing age-group (p = 0.001) but the type of isolates did not vary with age except forCitrobacter, Escherichia coli, Klebsiella, Salmonella, andEnterococcus species. Gram negative bacteria predominated in our study (59.8 %, n = 867/1451), but the commonest bacterial isolate wasStaphylococcus aureus (21.9 %, n = 318/1451)—and this trend run through the various age-groups. From 2010 to 2013, we observed a significant trend of yearly increase in the frequency of BSI caused by cephalosporin-resistant enterobacteria (Chi square for trend, p = 0.001). Meropenem maintained high susceptibility among all Gram-negative organisms ranging from 96 to 100 %. AmongStaphylococcus aureus, susceptibility to cloxacillin was 76.6 %. Conclusion Our study shows a significantly high blood culture positivity in infants as compared to children, adults and the elderly. There was a preponderance ofS. aureus and Gram-negative bacteria across all age-groups. Meropenem was the most active antibiotic for Gram-negative bacteria. Cloxacillin remains a very useful anti-staphylococcal agent.