Association of MMP-2 gene haplotypes with thoracic aortic dissection in chinese han population. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Liu, Ou; Li, Jiachen; Xin, Yi; Qin, Yanwen; Li, Haiyang; Gong, Ming; Liu, Yuyong; Wang, Xiaolong; Li, Jianrong; Zhang, Hongjia
• Is Part Of: BMC cardiovascular disorders. Volume 16:Issue 1(2016)
• Page Start: 1
• Page End: 8
• Publication Date: 2016-12
• Subjects: MMP-2 gene -- Single nucleotide polymorphism -- Thoracic aortic dissection; Cardiovascular system -- Diseases -- Periodicals; 616.12005
• DOI: 10.1186/s12872-016-0188-4
• Languages: English
• ISSNs: 1471-2261

Abstract

Abstract Background Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population. Methods In our case–control study, we recruited 755 unrelated participants: 315 case participants with TAD and 440 controls. Twenty-two tag SNPs were selected from MMP-2 gene and were genotyped. Genotype data were analyzed by logistic regression. Results Although we did not find any significant association for MMP-2 SNPs using single-marker analysis, we identified many windows with haplotype frequencies significantly different between case participants and control participants using a variable-sized sliding-window strategy. In particular, the most significant association was shown by a 2-SNP window consisting of rs2241145 and rs9928731 (omnibus test: asymptotic Pasym = 7.48 × 10−5 and empirical Pemp = 0.001867). There were two protective haplotypes: CT (Pasym = 0.00303; odds ratio [OR], 0.403) and GC (Pasym = 0.000976; OR, 0.448). Conclusions MMP-2 haplotypes are associated with genetic susceptibility to thoracic aortic dissection in Chinese Han population.