Infection with Acinetobacter baumannii in an intensive care unit in the Western part of Romania. Issue 1 (March 2016)

• Record Type: Journal Article
• Authors: Lăzureanu, Voichița; Poroșnicu, Mirela; Gândac, Ciprian; Moisil, Teodora; Bădițoiu, Luminița; Laza, Ruxandra; Musta, Virgil; Crișan, Alexandru; Marinescu, Adelina-Raluca
• Is Part Of: BMC infectious diseases. Volume 16:Issue 1(2016)
• Page Start: 23
• Page End: 28
• Publication Date: 2016-03
• Subjects: Acinetobacter baumannii -- Intensive Care Unit -- Mechanical ventilation -- Antibiotic resistance -- Infection; Communicable diseases -- Periodicals; Sexually Transmitted Diseases -- Periodicals; 616.905
• DOI: 10.1186/s12879-016-1399-0
• Languages: English
• ISSNs: 1471-2334

Abstract

Abstract Background Acinetobacter baumannii is one of the main causes of morbidity and mortality in critical condition patients. The pathogen's ability to survive under a wide range of environment conditions and to persist for long periods of time on areas represents a frequent cause of endemic infection hotbeds especially in the Intensive Care Unit. The objectives of the study are: determining the 5-year incidence ofA. baumannii infection in patients admitted in the ICU which needed mechanical ventilation; the analysis of these cases regarding pathological antecedents; processing the data regarding these cases; gradual analysis of the susceptibility/resistance of isolatedA. baumannii strains; observing the emergence ofA. baumannii infection in patients transferred into the ICU. Methods We have performed an observational retrospective study regarding the incidence ofAcinetobacter baumannii infections in the Intensive Care Unit of the Hospital of Infectious Diseases and Pneumophtisiology "Victor Babes" Timisoara, Clinic II Infectious Diseases, during June 2011 – June 2015. Results We have identified a high prevalence ofAcinetobacter baumannii infection, with an average period of 6 days. Bronchial suction was the most common pathological product in the study (90 % of the cases). Resistance to antimicrobials has been determined: the lowest resistance was recorded for ampicillin + sulbactam (81.1 %), and the highest resistance rate was recorded for ceftazidime and imipenem (94.6 % each). When comparing resistance to third generation cephalosporins, the difference was not statistically significant (94.6 % for ceftazidime vs. 86.5 % for cefoperazone, p = 0.117). Within the present study we were able to observe a significantly high resistance of the germ to carbapenems, with a good sensitivity to aminoglycosides, and to colistin. Only one strain ofAcinetobacter baumannii was resistant to all classes of tested antibiotics. Conclusions Generally, carbapenems represented the elective treatment in severe infections; however, the number of carbapenem-resistantAcinetobacter baumannii strains is growing, dramatically reducing therapeutic options, fact that brings back to our attention reusing colistin, although the administration of this antibiotic has been limited due to new antibiotics classes.