Investigation of blood flow in the external carotid artery and its branches with a new 0D peripheral model. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Ohhara, Yoshihito; Oshima, Marie; Iwai, Toshinori; Kitajima, Hiroaki; Yajima, Yasuharu; Mitsudo, Kenji; Krdy, Absy; Tohnai, Iwai
• Is Part Of: Biomedical engineering online. Volume 15:Issue 1(2016)
• Page Start: 1
• Page End: 17
• Publication Date: 2016-12
• Subjects: Blood flow -- External carotid artery and its branches -- 0D peripheral model -- Computational fluid dynamics -- Simulation -- Oral cancer -- Intra-arterial chemotherapy; Biomedical engineering -- Periodicals; 610.2805
• DOI: 10.1186/s12938-016-0133-x
• Languages: English
• ISSNs: 1475-925X

Abstract

Abstract Background Patient-specific modelling in clinical studies requires a realistic simulation to be performed within a reasonable computational time. The aim of this study was to develop simple but realistic outflow boundary conditions for patient-specific blood flow simulation which can be used to clarify the distribution of the anticancer agent in intra-arterial chemotherapy for oral cancer. Methods In this study, the boundary conditions are expressed as a zero dimension (0D) resistance model of the peripheral vessel network based on the fractal characteristics of branching arteries combined with knowledge of the circulatory system and the energy minimization principle. This resistance model was applied to four patient-specific blood flow simulations at the region where the common carotid artery bifurcates into the internal and external carotid arteries. Results Results of these simulations with the proposed boundary conditions were compared with the results of ultrasound measurements for the same patients. The pressure was found to be within the physiological range. The difference in velocity in the superficial temporal artery results in an error of 5.21 ± 0.78 % between the numerical results and the measurement data. Conclusions The proposed outflow boundary conditions, therefore, constitute a simple resistance-based model and can be used for performing accurate simulations with commercial fluid dynamics software.