Dissemination of clonal complex 2 Acinetobacter baumannii strains co-producing carbapenemases and 16S rRNA methylase ArmA in Vietnam. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Tada, Tatsuya; Miyoshi-Akiyama, Tohru; Shimada, Kayo; Nga, Tran; Thu, Le; Son, Nguyen; Ohmagari, Norio; Kirikae, Teruo
• Is Part Of: BMC infectious diseases. Volume 15:Issue 1(2015)
• Page Start: 1
• Page End: 7
• Publication Date: 2015-12
• Subjects: Multidrug-resistance -- Acinetobacter baumannii -- 16S rRNA methylase ArmA -- Metallo-β-lactamase NDM-1 -- Intensive care unit; Communicable diseases -- Periodicals; Sexually Transmitted Diseases -- Periodicals; 616.905
• DOI: 10.1186/s12879-015-1171-x
• Languages: English
• ISSNs: 1471-2334

Abstract

Abstract Background Acinetobacter baumannii strains co-producing carbapenemase and 16S rRNA methylase are highly resistant to carbapenems and aminoglycosides. Methods Ninety-three isolates of multidrug-resistantA. baumannii were obtained from an intensive care unit in a hospital in Vietnam. Antimicrobial susceptibility tests and whole genome sequencing were performed. Multilocus sequence typing and the presence of drug resistant genes were determined and a maximum-likelihood phylogenetic tree was constructed by SNP alignment of whole genome sequencing data. Results The majority of isolates belonged to clonal complex 2 (ST2, ST570 and ST571), and carried carbapenemase encoding genesbla OXA-23 andbla OXA-66 . Two isolates encoded carbapenemase genesbla NDM-1 andbla OXA-58 and the 16S rRNA methylase encoding genearmA and did not belong to clonal complex 2 (ST16). Conclusion A. baumannii isolates producing 16S rRNA methylase ArmA and belonging to clonal complex 2 are widespread, and isolates co-producing NDM-1 and ArmA are emerging, in medical settings in Vietnam.