Prins‐Driven Friedel–Crafts Reaction for the Stereoselective Synthesis of Hexahydroindeno[2, 1‐c]pyran Derivatives. Issue 11 (7th September 2015)

• Record Type: Journal Article
• Authors: Reddy, B. V. Subba; Reddy, G. Niranjan; Reddy, M. Ramana; Lakshmi, J. K.; Jagadeesh, B.; Sridhar, B.
• Is Part Of: Asian journal of organic chemistry. Volume 4:Issue 11(2015:Nov.)
• Page Start: 1266
• Page End: 1272
• Publication Date: 2015-09-07
• Subjects: carbonyl compounds -- (E)-3, 5-diphenylpent-4-en-1-ol -- domino cyclization -- γ, δ-unsaturated alcohols -- hexahydroindeno[2, 1-c]pyrans; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201500218
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: A strategy has been devised for the stereoselective synthesis of hexahydroindeno[2, 1‐ c ]pyran scaffolds through a domino cyclization of ( E )‐3, 5‐diphenylpent‐4‐en‐1‐ol with aldehydes using BF3 ⋅ OEt2 at 70 °C. It is an approach for the construction of the indeno[2, 1‐ c ]pyran skeleton in a one‐pot operation through a cascade cyclization. Abstract : Falling like dominos : A strategy has been developed for the stereoselective synthesis of hexahydroindeno[2, 1‐ c ]pyran scaffolds through a domino cyclization.