A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Lefrançois, Philippe; Chapdelaine, Hugo; Côté, Benoît; Desrosiers, Martin
• Is Part Of: Allergy, asthma, and clinical immunology. Volume 12:Issue 1(2016)
• Page Start: 1
• Page End: 5
• Publication Date: 2016-12
• Subjects: Chronic rhinosinusitis -- Auto-immunity -- IgE -- Blistering skin disorders -- Bullous pemphigoid; Allergy -- Periodicals; Immunology -- Periodicals; 616.97005
• DOI: 10.1186/s13223-016-0141-1
• Languages: English
• ISSNs: 1710-1492

Abstract

Abstract Chronic rhinosinusitis (CRS) is a frequent chronic condition, which has origins in complex interactions between genetic, immunological and microbial factors. The role of auto-immunity in CRS remains unclear, although recent studies have started to emerge in CRS patient refractory to maximal medical management. We discuss the possible auto-immunity link between CRS and other skin diseases, in particular acquired bullous dermatoses, and review the current evidence. We raise additional considerations for auto-immunity from both research and clinical standpoints.