SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma. Issue 1 (December 2016)

• Record Type: Journal Article
• Authors: Narurkar, Roshni; Alkayem, Mohammad; Liu, Delong
• Is Part Of: Biomarker research. Volume 4:Issue 1(2016)
• Page Start: 1
• Page End: 3
• Publication Date: 2016-12
• Subjects: Biochemical markers -- Periodicals
• DOI: 10.1186/s40364-016-0060-9
• Languages: English
• ISSNs: 2050-7771

Abstract

Abstract Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis.