Nicorandil-induced penile ulceration: a case report. (December 2016)

• Record Type: Journal Article
• Authors: Yap, Darren; Aboumarzouk, Omar; Bates, Christopher
• Is Part Of: Journal of medical case reports. Volume 10:Number 1(2016)
• Page Start: 1
• Page End: 3
• Publication Date: 2016-12
• Subjects: Penile -- Nicorandil -- Ulceration -- Nicotinamide -- Anti-anginal; Medicine -- Research -- Periodicals; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1186/s13256-016-0987-3
• Languages: English
• ISSNs: 1752-1947

Abstract

Abstract Background Penile ulceration in older patients is commonly neoplastic or infective. However, there are rarer causes of these ulcerations that we have to exclude. We present a rare complication of penile ulceration secondary to nicorandil, a nicotinamide ester. Case presentation An 86-year-old white British man was referred with a bloody discharge from under his phimotic foreskin and a lump on the shaft of his penis for the past year. He had angina which has been controlled with nicorandil for the past 5 years. A surgical biopsy of the ulcer showed inflammation with no evidence of malignancy. His penile ulceration spontaneously resolved when he stopped his nicorandil treatment. Conclusions Nicorandil-induced ulceration is a rare complication; however, it should not be missed in a clinical setting. If there is any doubt about the cause of penile ulceration, then referral to dermatology or urology for consideration of biopsy is essential.