Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population. Issue 6 (21st January 2019)

• Record Type: Journal Article
• Authors: Zhu, Xiao‐Bo; Zhuo, Ling‐Yun; Yue, Ming; Liu, Mei; Zang, Feng; Fan, Hao‐Zhi; Wu, Jing‐Jing; Xia, Xue‐Shan; Zhang, A‐Mei; Yu, Rong‐Bin; Huang, Peng
• Is Part Of: Journal of medical virology. Volume 91:Issue 6(2019)
• Page Start: 1097
• Page End: 1103
• Publication Date: 2019-01-21
• Subjects: DDX58 -- hepatitis C -- interferon‐induced helicase C domain‐containing protein 1 -- single‐nucleotide polymorphisms -- spontaneous clearance; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25398
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : Aims: To investigate the association between two RIG‐I‐ like receptor gene polymorphisms and hepatitis C virus (HCV) infection in Chinese Han population. Methods: The current study genotyped two selected SNPs ( IFIH1 rs3747517 and DDX58 rs9695310) using TaqMan allelic discrimination assay to assess their association with the susceptibility and clinical outcome of HCV infection among 3065 participants (1545 non‐HCV infection individuals, 568 spontaneous HCV clearance cases, and 952 persistent infection patients). Results: IFIH1 rs3747517 (dominant model: Adjusted odds ratio [OR] = 1.34, 95% confidence interval [CI] = 1.07‐1.68; P = 0.009) and DDX58 rs9695310 (dominant model: Adjusted OR = 1.43, 95% CI = 1.15‐1.78; P = 0.001) were associated with chronic hepatitis C (CHC). And the risk of CHC increased when people were carrying more unfavorable rs3747517‐GA/AA and rs9695310‐GC/CC genotypes from zero to two with the chronic rates of 56.72%, 59.38%, and 69.01%, respectively ( P trend < 0.001). Conclusion: Genetic variations at IFIH1 rs3747517 and DDX58 rs9695310 were independent predictors of chronic hepatitis C in Chinese Han population. Highlights: DEAD (Asp‐Glu‐Ala‐Asp) box protein 58 (DDX58) and interferon‐induced helicase C domain‐containing protein 1 (IFIH1) are cytologic RNA helicase protein and important initiators of innate immune response to RNA virus infection, which may play an indelible role in hepatitis C virus (HCV) infection outcomes. This study was conducted to investigate the association of IFIH1 rs3747517 and DDX58 rs9695310 with HCV clearance in Chinese Han population.