Cover Feature: A Thermodynamic Model of Auto‐regulated Protein Assembly by a Supramolecular Scaffold (ChemPhysChem 8/2019). Issue 8 (5th April 2019)

• Record Type: Journal Article
• Authors: Rennie, Martin L.; Crowley, Peter B.
• Is Part Of: Chemphyschem. Volume 20:Issue 8(2019)
• Page Start: 994
• Page End: 994
• Publication Date: 2019-04-05
• Subjects: Bayesian fitting -- calix[8]arene -- cytochrome c -- multi-body -- oligomerization; Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cphc.201900325
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract : The Cover Feature illustrates auto‐regulated protein assembly in which a supramolecular ligand prompts tetramer formation and subsequent disassembly to a ligand‐coated monomer. Highly atypical isothermal titration calorimetry thermograms were obtained for the interactions of anionic sulfonato‐calix[8]arene and cationic cytochrome c. A modelling approach with Bayesian fitting provides new tools to understand such intricate assembly processes. More information can be found in the Article by M. L. Rennie and P. B. Crowley onpage 1011 in Issue 8, 2019 (DOI:10.1002/cphc.201900153 ).