Biliary tract cancer incidence and trends in the United States by demographic group, 1999‐2013. Issue 9 (15th January 2019)

• Record Type: Journal Article
• Authors: Van Dyke, Alison L.; Shiels, Meredith S.; Jones, Gieira S.; Pfeiffer, Ruth M.; Petrick, Jessica L.; Beebe‐Dimmer, Jennifer L.; Koshiol, Jill
• Is Part Of: Cancer. Volume 125:Issue 9(2019)
• Page Start: 1489
• Page End: 1498
• Publication Date: 2019-01-15
• Subjects: biliary tract -- cancer -- incidence -- trends -- United States; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.31942
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Background: Biliary tract cancers (BTCs) are rare but deadly cancers (gallbladder cancer [GBC], intrahepatic cholangiocarcinoma [ICC], extrahepatic cholangiocarcinoma [ECC], and ampulla of Vater cancer [AVC]). A recent US study reported increasing GBC incidence among people younger than 45 years and blacks; however, it did not examine trends for other biliary tract sites. Methods: This study characterized demographic differences in BTC incidence rates and time trends by anatomic site. Population‐based North American Association of Central Cancer Registries data were used to calculate age‐adjusted incidence rates, incidence rate ratios (IRRs), and estimated annual percent changes (eAPCs) for 1999‐2013 by site and demographic group. For sites with significant differences in eAPC by age group, IRRs were compared by age group. Results: GBC incidence rates declined among women (eAPC, –0.5%/y; P = .01) and all racial/ethnic groups except for non‐Hispanic blacks, among whom rates increased (1.8%/y; P < .0001). Although GBC rates increased among 18‐ to 44‐year‐olds (eAPC, 1.8%/y; P = .01), they decreased among people 45 years old or older (–0.4%/y; P = .009). Sex ( P < .0001) and racial/ethnic differences ( P = .003 to .02) in GBC incidence were larger for younger people than older people. During this period, ICC (eAPC, 3.2%/y; P < .0001) and ECC rates (1.8%/y; P = .001) steadily increased across sex and racial/ethnic groups. Although AVC incidence rates increased among younger adults (eAPC, 1.8%/y; P = .03) but not older adults (–0.20%/y; P = .30), sex and racial/ethnic IRRs did not differ by age. Conclusions: Differential patterns of BTC rates and temporal trends have been identified by anatomic site and demographic groups. These findings highlight the need for large pooling projects to evaluate BTC risk factors by anatomic site. Abstract : Significant and novel variations in biliary tract cancer incidence rates and trends are identified across anatomic sites by demographic group among adults in the United States between 1999 and 2013. Differences in sex‐ and race/ethnicity‐specific gallbladder cancer incidence rate ratios are larger among younger adults than older adults, and this may reflect underlying differences in the prevalence of and trends in risk factors by demographic group.